28. Cancer Stem Cells

Cancer Stem Cells: Making Sense of the Data

The CSC research space is proving to be challenging and fraught with controversy

There is much controversy in the CSC field as to their surface phenotype, intercellular pathways, and role in metastatic progression.

The focus of this GEN Market & Tech Analysis report is to frame the challenging space of cancer stem cells (CSCs). Highlights of this report:

The potential relationship between circulating tumor cells (CTCs) and CSCs is unclear at present—this is important since it underlines the mechanism[s] by which components of the primary tumor migrate to distal sites and induce mets, the drivers for morbidity and mortality in late-stage cancer patients.We have performed market surveys of researchers studying CSCs as a means to understand the surface markers deployed (to characterize CSCs) as well as the intracellular signal transduction pathways being studied in the context of CSCs.Also presented in this report are the various associations of markers with distinct cancer classes documented thusfar—it appears that distinct classes of CSCs with different surface phenotypes may be associated with different classes of cancer and would suggest that the CSC pool is distinct in different cancer classes ("one size does not fit all").This space is an area of continuing industry coverage for us, and in future reports we'll document advances in the CSC space as they occur as well as an update on the clinical trials underway in this field.
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