3. Skin-to-Liver Cell Shortcut

Researchers use an adapted reprogramming technique to generate hepatocytes for the repopulation of an injured mouse liver




Scientists have differentiated human induced pluripotent stem cells (iPSCs) into hepatocytes in a dish, but faced challenges using these cells therapeutically. Most iPSC-derived liver cells do not adequately proliferate after transplantation or function exactly like adult hepatocytes do. Now, researchers from the University of California, San Francisco (UCSF), have differentiated human hepatocytes with a modified technique that bypasses pluripotency, and used these cells to repopulate a mouse liver. Their work was published in Nature today (February 23).

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